Corrigendum: Chloroquine enhanced the anticancer capacity of VNP20009 by inhibiting autophagy
نویسندگان
چکیده
“The authors are grateful to grants from the Doctoral Station Science Foundation from the Chinese Ministry of Education (20130091130003), the Nature Science Foundation of China (81421091), the Jiangsu Provincial Nature Science Foundation (BE2013630), the Open Project Programs from State Key Laboratory of Natural Medicines of China Pharmaceutical University (G140014) and The State Key Laboratory of Bioelectronics of Southeast University, the Bureau of Science and Technology of Changzhou (CZ20130011, CE20135013)”.
منابع مشابه
Chloroquine enhanced the anticancer capacity of VNP20009 by inhibiting autophagy
Bacteria-based living anticancer agents have emerged as promising therapeutics. However, the functional role of autophagy in bacterial cancer therapy has been little investigated. In this study, Salmonella VNP20009 induced autophagy in B16F10 cells, which is an unfavorable factor in bacterial cancer therapy. Inhibiting the induction of autophagy by chloroquine or siRNA in bacterial cancer thera...
متن کاملBlockage of autophagy pathway enhances Salmonella tumor-targeting
Previous studies have shown that strains of Salmonella typhimurium specifically target tumors in mouse models of cancer. In this study, we report that tumor-targeting Salmonella typhimurium A1-R (A1-R) or VNP20009 induced autophagy in human cancer cells, which serves as a defense response. Functionally, by knockdown of essential autophagy genes Atg5 or Beclin1 in bacteria-infected cancer cells,...
متن کاملTumor vessel normalization by chloroquine independent of autophagy.
Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. We report that CQ reduced tumor growth but improved the tumor milieu. By normalizing tumor vessel structure and function and increasing perfusion, CQ reduced hypoxia, cancer cell invasion, and metastasis, while improving chemotherapy delivery...
متن کاملChloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature
Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and metastasis, while improving chemotherapy response, largely through an autophagy-independent, NOTCH1...
متن کاملChloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis
Sunitinib based adjuvant chemotherapy combined with chloroquine (CQ) for the treatment of renal cell carcinoma (RCC) is in clinical trials; however, its anti-RCC effect and the mechanism remain unclear. In the present study, the anti-RCC effect of sunitinib with CQ and the underlying mechanism was investigated. An MTT assay demonstrated that CQ enhanced the proliferation inhibitory effect of su...
متن کامل